Inducable nitric oxide may be at the heart of the heat health.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574120/
Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages
Ching-Wen Chen,1 Sho Tone Lee,2 Wen Tung Wu,1 Wen-Mei Fu,1 Feng-Ming Ho,3 and Wan Wan Lin1*
*Author for correspondence: Email: wwl@ha.mc.ntu.edu.tw
ABSTRACT
In conclusion, vanilloids can modulate the expression of inflammatory iNOS and COX-2 genes in macrophages through interference with upstream signalling events of LPS and IFN-γ. These findings provide new insights into the potential benefits of the active ingredient in hot chilli peppers in inflammatory conditions.
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